The National Park is one of the largest (1,523,000 ha) and most intact parks in the Amazon Basin. With an altitudinal range of 200 m to nearly 1,000 m, it is the site of a rich mosaic of habitat types from Cerrado savannah and forest to upland evergreen Amazonian forests. The park boasts an evolutionary history dating back over a billion years to the Precambrian period. An estimated 4,000 species of flora as well as over 600 bird species and viable populations of many globally endangered or threatened vertebrate species live in the park.

Criteria (ix) and (x): The site contains an array of habitat types including evergreen rainforests, palm forests, cerrado, swamps, savannahs, gallery forests, and semi-deciduous dry forests. The cerrado habitats found on the Huanchaca Meseta have been isolated for millions of years providing an ideal living laboratory for the study of the evolution of these ecosystems. The site also contains a high diversity of plant and animal species, including viable populations of many globally threatened large vertebrates.